Can Ozempic cause muscle pain? Expert explained

can ozempic cause muscle pain

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The popularity of Ozempic not only due to the fight against diabetes, but also due to its side effect – weight loss – is causing more and more questions about its performance and side effects. One of the question related to Ozempic and it side effect – Can Ozempic cause muscle pain? In this article I will try to answer it.

Key takeaways of Ozempic and muscle pain

Diarrhea and nausea are common side effects of omemplified medications. Some Ozempic users report experiencing excruciating joint and muscle pain.

As of right now, Ozempic is not linked to any joint or muscle pain. There could be another cause for the symptoms, such as underlying medical issues. Feel free to skip to part of article that interest you the most from table of contents below.

Table of contents

Can Ozempic cause muscle pain: answer

No, pain, or discomfort in the muscles, is not known to be a side effect of Ozempic®. Typical Ozempic side effects include heartburn, nausea, upset stomach, constipation, and diarrhea.

You can have some soreness where the injection was made because it is an injectable drug. Remember that Ozempic is injected subcutaneously—that is, into fat rather than straight into muscle.

Muscle pain can result from a variety of factors, such as trauma, viral infections, overexertion, and some drugs.

can ozempic cause muscle pain
Does Ozempic cause muscle pain?

As a result, it’s crucial to consult your doctor if you feel muscle soreness while taking Ozempic in order to identify the cause and the best course of action.

FDA approves: muscle pain is not side effect

The FDA does not currently list muscle pain as a known side effect of taking semaglutide. “Ozempic does not have a direct impact on skeletal muscle,” explains doctor.

She also notes that muscle pain is subjective and further investigation is needed to determine if it is related to lack of exercise or another factor.

Some users of the weight-loss drug experience muscle pain. One possible explanation is muscle pain at the injection site, similar to the pain we feel after a flu shot. 

Additionally, rapid weight loss can cause fatigue, aches, and pains due to body and hormonal changes. These symptoms may be a result of women eating significantly less while on this drug.

There is currently no research linking Ozempic to muscle pain. However, there are concerns about the drug’s impact on muscle mass. A clinical trial in 2021 discovered that approximately 40% of the weight loss observed with semaglutide (the active ingredient in Ozempic) came from lean mass, including muscle tissue. 

This is particularly worrisome as it is worse than the results seen with other rapid weight-loss methods such as fad diets and gastric bypass.

Health, emphasizes that losing weight, regardless of the method, will result in some loss of muscle mass. She further states that faster weight loss, which can occur with bariatric surgery or highly effective medications like Ozempic, may lead to a greater reduction in muscle.

Can Ozempic cause leg pain?

While leg discomfort is not an uncommon side effect of Ozempic, some people may experience it. Although the precise origin of Ozempic leg discomfort is unknown, it might be connected to how the drug affects blood flow and blood sugar levels.

So if you ask does Ozempic make your legs hurt I can say that it is not due to this particular medication, but because of possible disease.

Ozempic Leg Pain Symptoms

Olympic leg soreness can appear in a variety of ways. Some people may have severe, shooting sensations in their legs, while others may only feel a dull discomfort or cramping. One leg may be the only one affected, or both legs may be affected.

Ozempic leg pain symptoms that could coexist with it include:

  • Inflammation or edema in the legs
  • Sensitivity or tingling
  • Deficiency
  • Having trouble standing or walking

Options for Treating Leg Pain in the Olympics

There are various ways to address leg pain that you may be having while taking Ozempic in order to help relieve your symptoms.

It’s crucial to remember that you should always talk to your doctor before stopping or modifying your Ozempic dosage.

can Ozempic cause leg pain
Can Ozempic cause muscle pain?

1. Pain Relief: Acetaminophen or ibuprofen, two over-the-counter pain medicines, can help with mild to moderate leg discomfort.

Before taking any drug, though, make sure to speak with your doctor and adhere to the specified dosage.

2. Physical treatment: Stretches and exercises for physical therapy can help strengthen your leg muscles, lower inflammation, and increase blood flow.

A physical therapist can design a customized workout program to meet your unique requirements.

3. Lifestyle Adjustments: A few lifestyle adjustments can also aid in the treatment of Olympic leg discomfort. Keeping a healthy weight, working out frequently, avoiding extended periods of sitting or standing, and dressing comfortably are a few examples.

Leg discomfort can be difficult to manage as a side effect of Ozempic, but it can be relieved with the appropriate care plan.

It is crucial to speak with your healthcare professional if you are taking Ozempic and are having leg discomfort in order to receive an accurate diagnosis and treatment recommendations. I hope now you understand more on can Ozempic cause leg pain question.

FAQ of Ozempic and muscle pain

When taking Ozempic, should I be concerned about muscle soreness?

Notifying your healthcare doctors of any severe or ongoing muscle discomfort you feel while taking Ozempic is crucial. They can determine whether the drug is causing the symptoms or if there are any other possible causes of the muscle soreness.

Should I quit taking Ozempic if I feel discomfort in my muscles?

Don’t stop taking Ozempic without first talking to your doctor. They are able to evaluate your symptoms, identify the reason behind your muscle soreness, and offer suitable advice.

If you want to know more about Ozempik I suggest you to visit our blog on

Muscle loss for older women

Muscle loss can be a challenging issue for individuals over 50, as it becomes increasingly difficult to regain muscle as one ages. This age-related loss of muscle is referred to as sarcopenia.

Weight-loss medications can increase the risk of muscle loss in women. After menopause, there is a rapid decline in muscle mass, but men are not affected as much due to testosterone protecting skeletal muscle.

The rotator cuff muscles often weaken with age, and the thin fascia layers in that area can easily tear. It is particularly important for women to strengthen this muscle group.

How to relieve muscle pain? Tips

  • Massage: Blood circulation can be improved and muscle tension can be released with a gentle massage. You can try using a foam roller, your hands, or a licensed massage therapist’s help.
  • Stretching: Mild stretching techniques can aid in reducing muscular stiffness and increasing flexibility. Stretch carefully, holding each pose for a minimum of 15 to 30 seconds.
  • Consuming a lot of water: Muscle function depends on enough hydration. Make sure you are getting adequate water, particularly if you exercise regularly.
  • Be active: Mild, low-impact physical activities can assist keep muscles flexible and avoid them from stiffening up. A healthcare provider should be consulted before beginning any new fitness regimen.
  • Get Enough Sleep: Make sure you’re getting adequate restorative sleep because it’s essential for the repair of your muscles.

Summary of Can Ozempic cause muscle pain

  • As of right now, Ozempic is not linked to any joint or muscle pain. It’s also possible that an underlying medical ailment is causing the symptoms.
  • Furthermore, rapid weight loss may induce fatigue, aches, and pains due to physical and hormonal changes.This medicine may cause these symptoms in women who eat significantly less.

I hope I answered you the question “Can Ozempic cause muscle pain”. However this information should not be considered a substitute for professional medical advice or diagnosis. Also if we talking about can Ozempic cause leg pain too.

It is always important to consult with your physician before pursuing any treatment plan. And you will use this medicine (if it is necessary for you) and don’t feel muscle pain.

I also suggest to read related article of mine named “What is “Ozempic face” and what can individuals do to prevent it?“. It is great and helpful review.

  1. Collins, L. (2023, January 13). Glucagon-like Peptide-1 Receptor Agonists. StatPearls – NCBI Bookshelf.
  2. Rai, P., Dwibedi, N., Rowneki, M., Helmer, D. A., & Sambamoorthi, U. (2019). Dipeptidyl Peptidase-4 Inhibitors and Joint Pain: A Retrospective Cohort Study of Older Veterans with Type 2 Diabetes Mellitus. American health & drug benefits12(5), 223–231.
  3. Acute Kidney Injury (AKI). (2022, August 11). National Kidney Foundation.
  4. Bartel, M. (2023, April 18). Acute Pancreatitis. Merck Manuals Professional Edition

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